Year 2015; Volume 1; Issue 4

Simultaneous Spectrophotometric Estimation of Diloxanide Furoate and Metronidazole in Tablet Dosage Form

Author: Danao KR*, Hiradeve SM, Bobade TS, Dumore NG, Gupta RA, Motiwala MN

Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India

Abstract

Two simple, fast, precise and specific validated spectrophotometric methods were developed for simultaneous estimation of diloxanide furoate and metronidazole in synthetic mixture and its dosage form. Wavelengths selected for simultaneous equation method were 257 nm and 310 nm as well as wavelengths selected for absorption ratio method was 277 nm and 310 nm. Both methods were validated statistically according to International Conference on Harmonization and a recovery study was carried out to confirm the accuracy. The methods were successfully applied to pharmaceutical formulation with no interference from excipients.
Keywords: Diloxanide furoate, Metronidazole, Simultaneous equation, Absorption ratio and Method validation


Kishor R. Danao
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India
Article Type : Research Article
Date : 2015-09-29
No of Downloads : 724